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Article

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity.

PLoS pathogens - 1 Oct 2020

Ikegame Satoshi, Beaty Shannon M, Stevens Christian, Won Taylor, Park Arnold, Sachs David, Hong Patrick, Lee Benhur, Thibault Patricia A

Abstract excerpt

The antigenic and genomic stability of paramyxoviruses remains a mystery. Here, we evaluate the genetic plasticity of Sendai virus (SeV) and mumps virus (MuV), sialic acid-using paramyxoviruses that infect mammals from two Paramyxoviridae subfamilies (Orthoparamyxovirinae and Rubulavirinae). We performed saturating whole-genome transposon insertional mutagenesis, and identified important commonalities: disordered...

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Identifiers

PMID: 33035269
DOI: 10.1371/journal.ppat.1008877
PMCID: PMC7577504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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