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Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

2020-03-31

Abstract excerpt

The antigenic and genomic stability of paramyxoviruses remains a mystery. Here, we evaluate the genetic plasticity of Sendai virus (SeV) and mumps virus (MuV), sialic acid-using paramyxoviruses that infect mammals from two Paramyxoviridae subfamilies ( Orthoparamyxovirinae and Rubulavirinae ). We performed saturating whole-genome transposon insertional mutagenesis, and identified important commonalities: disord...

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Literature Corpus work
b5eebf5d-9103-54ab-89c3-bbfdd773d46e
DOI
10.1101/2020.03.30.016493
Open publication

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Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticityDOI 10.1101/2020.03.30.016493
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