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Article

Involvement of circulating factors in the transmission of paternal experiences through the germline.

The EMBO journal - 1 Dec 2020

van Steenwyk Gretchen, Gapp Katharina, Jawaid Ali, Germain Pierre-Luc, Manuella Francesca, Tanwar Deepak K, Zamboni Nicola, Gaur Niharika, Efimova Anastasiia, Thumfart Kristina M, Miska Eric A, Mansuy Isabelle M

Abstract excerpt

Environmental factors can change phenotypes in exposed individuals and offspring and involve the germline, likely via biological signals in the periphery that communicate with germ cells. Here, using a mouse model of paternal exposure to traumatic stress, we identify circulating factors involving peroxisome proliferator-activated receptor (PPAR) pathways in the effects of exposure to the germline. We show that...

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Source

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Identifiers

PMID: 33034389
DOI: 10.15252/embj.2020104579
PMCID: PMC7705452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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