Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring.

doi:10.1073/pnas.1305609111

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Article

Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring.

Proceedings of the National Academy of Sciences of the United States of America - 11 Feb 2014

Bromfield John J, Schjenken John E, Chin Peck Y, Care Alison S, Jasper Melinda J, Robertson Sarah A

Abstract excerpt

Paternal characteristics and exposures influence physiology and disease risks in progeny, but the mechanisms are mostly unknown. Seminal fluid, which affects female reproductive tract gene expression as well as sperm survival and integrity, provides one potential pathway. We evaluated in mice the consequences for offspring of ablating the plasma fraction of seminal fluid by surgical excision of the seminal...

Topics

Animals
Blood Pressure
Female
Genitalia, Female
Male
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Phenotype
Semen

Source

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Identifiers

PMID: 24469827
DOI: 10.1073/pnas.1305609111
PMCID: PMC3926084

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