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15-Deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> Induces Epithelial-tomesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation

28 Sept 2020

Abstract excerpt

In inflammation-associated carcinogenesis, COX-2 is markedly overexpressed, resulting in accumulation of various prostaglandins. 15-deoxy- 12,14 -prostaglandin J 2 (15d-PGJ 2 ) is one of the terminal products of COX-2-catalyzed arachidonic acid catabolism with oncogenic potential. Epithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells lose their polarity and adhesiveness, and thereby...

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PMID: 33033709
DOI: 10.15430/jcp.2020.25.3.152

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