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Article

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

19 Jul 2020

Abstract excerpt

There is increasing evidence for a role of inflammation in Parkinson's disease. Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. Specifically, the CGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes) pathway mitigates activation of the innate immune...

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PMID: 33029617
DOI: 10.1093/brain/awaa246

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