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Article

Molecular diversity in uterine carcinosarcoma: Beyond TP53.

Gynecologic oncology - 1 Jul 2025

Pham Eveline N B, van den Berg Caroline B, Kokke Nina C C J, van Marion Ronald, Dollée Dennis, Boere Ingrid A, Groenendijk Floris H, van Beekhuizen Heleen J

Abstract excerpt

OBJECTIVE: This study conducted genomic profiling of uterine carcinosarcoma (UCS) to gain molecular insights, analyzing carcinoma and sarcoma components separately when possible. METHODS: Clinical and pathological data from UCS patients were collected, and tumor DNA was analyzed using next-generation sequencing to evaluate genomic alterations, microsatellite instability, tumor mutational burden (TMB), and...

Topics

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Carcinosarcoma
Class I Phosphatidylinositol 3-Kinases
Cyclin E
DNA Copy Number Variations
Microsatellite Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins

Tumor Suppressor Protein p53

Uterine Neoplasms

Source

Identifiers

PMID: 40446429
DOI: 10.1016/j.ygyno.2025.05.010

Genes

TP53
CCNE1
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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