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Article

The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2017

Ng Charlotte K Y, Piscuoglio Salvatore, Geyer Felipe C, Burke Kathleen A, Pareja Fresia, Eberle Carey A, Lim Raymond S, Natrajan Rachael, Riaz Nadeem, Mariani Odette, Norton Larry, Vincent-Salomon Anne, Wen Y Hannah, Weigelt Britta, Reis-Filho Jorge S

Abstract excerpt

Purpose: Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic type of breast cancer, predominantly of triple-negative phenotype, and characterized by the presence of malignant cells showing squamous and/or mesenchymal differentiation. We sought to define the repertoire of somatic genetic alterations and the mutational signatures of MBCs.Experimental Design: Whole-exome sequencing was performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28153863
DOI: 10.1158/1078-0432.CCR-16-2857
PMCID: PMC5511565

Genes

FAT1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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