Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.

doi:10.1038/s41588-020-0705-3

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Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease.

Nature genetics - 1 Nov 2020

Koyama Satoshi, Ito Kaoru, Terao Chikashi, Akiyama Masato, Horikoshi Momoko, Momozawa Yukihide, Matsunaga Hiroshi, Ieki Hirotaka, Ozaki Kouichi, Onouchi Yoshihiro, Takahashi Atsushi, Nomura Seitaro, Morita Hiroyuki, Akazawa Hiroshi, Kim Changhoon, Seo Jeong-Sun, Higasa Koichiro, Iwasaki Motoki, Yamaji Taiki, Sawada Norie, Tsugane Shoichiro, Koyama Teruhide, Ikezaki Hiroaki, Takashima Naoyuki, Tanaka Keitaro, Arisawa Kokichi, Kuriki Kiyonori, Naito Mariko, Wakai Kenji, Suna Shinichiro, Sakata Yasuhiko, Sato Hiroshi, Hori Masatsugu, Sakata Yasushi, Matsuda Koichi, Murakami Yoshinori, Aburatani Hiroyuki, Kubo Michiaki, Matsuda Fumihiko, Kamatani Yoichiro, Komuro Issei

Abstract excerpt

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we conducted a large-scale genome-wide association study of 168,228 individuals of Japanese ancestry (25,892 cases and 142,336 controls) with genotype imputation using a newly developed reference panel of Japanese haplotypes including 1,781 CAD cases and 2,636 controls. We detected eight new susceptibility loci and...

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PMID: 33020668
DOI: 10.1038/s41588-020-0705-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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