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Article

Integrated DNA and RNA sequencing reveals targetable alterations in metastatic pediatric papillary thyroid carcinoma.

Pediatric blood & cancer - 1 Jan 2021

Potter Samara L, Reuther Jacquelyn, Chandramohan Raghu, Gandhi Ilavarasi, Hollingsworth Faith, Sayeed Hadi, Voicu Horatiu, Kakkar Nipun, Baksi Koel Sen, Sarabia Stephen F, Lopez Monica E, Chelius Daniel C, Athanassaki Ioanna D, Mahajan Priya, Venkatramani Rajkumar, Quintanilla Norma M, Lopez-Terrada Dolores H, Roy Angshumoy, Parsons D Williams

Abstract excerpt

BACKGROUND: Pediatric papillary thyroid carcinoma (PTC) is clinically and biologically distinct from adult PTC. We sequenced a cohort of clinically annotated pediatric PTC cases enriched for high-risk tumors to identify genetic alterations of relevance for diagnosis and therapy. METHODS: Tumor DNA and RNA were extracted from FFPE tissue and subjected to next-generation sequencing (NGS) library preparation using a...

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Identifiers

PMID: 33009870
DOI: 10.1002/pbc.28741
PMCID: PMC13317003

Genes

BRAF
NTRK3
RET

Variants

Provenance

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