Article
Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions.
The oncologist - 1 Mar 2017
Vanden Borre Pierre, Schrock Alexa B, Anderson Peter M, Morris John C, Heilmann Andreas M, Holmes Oliver, Wang Kai, Johnson Adrienne, Waguespack Steven G, Ou Sai-Hong Ignatius, Khan Saad, Fung Kar-Ming, Stephens Philip J, Erlich Rachel L, Miller Vincent A, Ross Jeffrey S, Ali Siraj M
Abstract excerpt
BACKGROUND: Thyroid carcinoma, which is rare in pediatric patients (age 0-18 years) but more common in adolescent and young adult (AYA) patients (age 15-39 years), carries the potential for morbidity and mortality. METHODS: Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients,...
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