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Article

GnRH—A Key Regulator of FSH

4 Dec 2018

Abstract excerpt

The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive development and function. Activation of specific, high-affinity cell surface receptors (GnRH receptors) on gonadotropes by GnRH triggers signal transduction cascades to stimulate the coordinated synthesis and secretion of the pituitary gonadotropins FSH and LH. These hormones direct gonadal steroidogenesis and gametogenesis, making...

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PMID: 30517625
DOI: 10.1210/en.2018-00889

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