Article
Conformational disturbance in Abl kinase upon mutation and deregulation.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2009
Iacob Roxana E, Pene-Dumitrescu Teodora, Zhang Jianming, Gray Nathanael S, Smithgall Thomas E, Engen John R
Abstract excerpt
Protein dynamics are inextricably linked to protein function but there are few techniques that allow protein dynamics to be conveniently interrogated. For example, mutations and translocations give rise to aberrant proteins such as Bcr-Abl where changes in protein conformation and dynamics are believed to result in deregulated kinase activity that provides the oncogenic signal in chronic myelogeous leukemia....
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