Genomic Risk Score impact on susceptibility to systemic sclerosis.

doi:10.1136/annrheumdis-2020-218558

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Article

Genomic Risk Score impact on susceptibility to systemic sclerosis.

Annals of the rheumatic diseases - 1 Jan 2021

Bossini-Castillo Lara, Villanueva-Martin Gonzalo, Kerick Martin, Acosta-Herrera Marialbert, López-Isac Elena, Simeón Carmen P, Ortego-Centeno Norberto, Assassi Shervin, Hunzelmann Nicolas, Gabrielli Armando, de Vries-Bouwstra J K, Allanore Yannick, Fonseca Carmen, Denton Christopher P, Radstake Timothy Rdj, Alarcón-Riquelme Marta Eugenia, Beretta Lorenzo, Mayes Maureen D, Martin Javier

Abstract excerpt

OBJECTIVES: Genomic Risk Scores (GRS) successfully demonstrated the ability of genetics to identify those individuals at high risk for complex traits including immune-mediated inflammatory diseases (IMIDs). We aimed to test the performance of GRS in the prediction of risk for systemic sclerosis (SSc) for the first time. METHODS: Allelic effects were obtained from the largest SSc Genome-Wide Association Study...

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PMID: 33004331
DOI: 10.1136/annrheumdis-2020-218558

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