Article
Multiple pathways of cross-resistance to glycopeptides and daptomycin in persistent MRSA bacteraemia.
The Journal of antimicrobial chemotherapy - 1 Nov 2015
Chen Chih-Jung, Huang Yhu-Chering, Chiu Cheng-Hsu
Abstract excerpt
BACKGROUND: The development of non-susceptibility to glycopeptides and daptomycin in MRSA during persistent bacteraemia has become a significant therapeutic challenge. However, the in vivo evolution and mechanism of the dual resistance have remained incompletely understood. METHODS: A series of MRSA blood isolates with incremental non-susceptibility to glycopeptides and daptomycin were consecutively recovered...
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