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Article

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.

PloS one - 1 Jan 2020

Mitsumori Risa, Sakaguchi Kazuya, Shigemizu Daichi, Mori Taiki, Akiyama Shintaro, Ozaki Kouichi, Niida Shumpei, Shimoda Nobuyoshi

Abstract excerpt

The aim of the present study was to (1) investigate the relationship between late-onset Alzheimer's disease (AD) and DNA methylation levels in six of the top seven AD-associated genes identified through a meta-analysis of recent genome wide association studies, APOE, BIN1, PICALM, CR1, CLU, and ABCA7, in blood, and (2) examine its applicability to the diagnosis of AD. We examined methylation differences at CpG...

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PMID: 32991610
DOI: 10.1371/journal.pone.0239196
PMCID: PMC7523949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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