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Article

The protective role of estrogen on endothelial and glycocalyx barriers after shock conditions: A microfluidic study.

Surgery - 1 Mar 2021

Diebel Lawrence N, Wheaton Madison, Liberati David M

Abstract excerpt

BACKGROUND: Sexual dimorphism has been demonstrated after major trauma and hemorrhage shock with protective effects related to female sex or estrogen. Traumatic endotheliopathy is an important component of trauma-induced coagulopathy. Components of endothelial barrier dysfunction include degradation of the endothelial glycocalyx and endothelial cellular injury. Estrogen modulates endothelial function via its...

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Identifiers

PMID: 32988619
DOI: 10.1016/j.surg.2020.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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