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Article

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

2 Jun 2017

Abstract excerpt

BACKGROUND: Endothelial glycocalyx breakdown elicits syndecan-1 shedding and endotheliopathy of trauma (EoT). We hypothesized that a cutoff syndecan-1 level can identify patients with endothelial dysfunction who would have poorer outcomes. STUDY DESIGN: We conducted a prospective observational study. Trauma patients with the highest level of activation admitted from July 2011 through September 2013 were eligible....

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PMID: 28579548
DOI: 10.1016/j.jamcollsurg.2017.05.012

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