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Article

Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation.

The Journal of biological chemistry - 18 Nov 2011

Bolger Timothy A, Wente Susan R

Abstract excerpt

DEAD-box protein (Dbp) family members are essential for gene expression; however, their precise roles and regulation are not fully defined. During messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facilitate remodeling of mRNA-protein complexes. In contrast, here we define a novel Gle1 role in translation initiation through regulation of a different DEAD-box protein, the...

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Share to DEAD-box RNA Helicases
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Pore Complex Proteins

Share to Nucleocytoplasmic Transport Proteins

Share to Peptide Chain Initiation, Translational

Share to RNA, Fungal

Share to Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 21949122
DOI: 10.1074/jbc.M111.299321
PMCID: PMC3220593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiation.PMID 21949122Read ↗

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.Semantic proximity Read ↗

The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1.Semantic proximity Read ↗

The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.Semantic proximity Read ↗

Functions of Gle1 are governed by two distinct modes of self-associationSemantic proximity Read ↗

Functions of Gle1 are governed by two distinct modes of self-associationSemantic proximity Read ↗

Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1.Semantic proximity Read ↗

The DEAD-box RNA helicase Dbp5 functions in translation termination.Semantic proximity Read ↗

Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.Semantic proximity Read ↗

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.Semantic proximity Read ↗

Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding.Semantic proximity Read ↗

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