Article
Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization.
RNA (New York, N.Y.) - 1 Nov 2009
Müller Marisa, Richter Klaus, Heuck Alexander, Kremmer Elisabeth, Buchner Johannes, Jansen Ralf-Peter, Niessing Dierk
Abstract excerpt
In eukaryotic cells, dozens to hundreds of different mRNAs are localized by specialized motor-dependent transport complexes. One of the best-studied examples for directional mRNA transport is the localization of ASH1 mRNA in Saccharomyces cerevisiae. For transport, ASH1 mRNA is bound by the unusual RNA-binding protein She2p. Although previous results indicated that She2p forms dimers required for RNA binding and...
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