Article
Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages.
Frontiers in immunology - 1 Jan 2020
Le Yanqing, Cao Wenli, Zhou Lu, Fan Xin, Liu Qiangui, Liu Fusheng, Gai Xiaoyan, Chang Chun, Xiong Jing, Rao Yafei, Li Aling, Xu Wei, Liu Beibei, Wang Tong, Wang Beinan, Sun Yongchang
Abstract excerpt
Pulmonary tuberculosis (PTB) is a risk factor for COPD. Our previous study revealed more severe emphysema in COPD patients (mostly smokers) with prior tuberculosis. However, the mechanisms of interactions between cigarette smoke (CS) and Mycobacterium tuberculosis (Mtb) are unknown. In this study, we found that the frequencies of both M1 and M2 macrophages, and levels of MMP9 and MMP12 in bronchoalveolar lavage...
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