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Article

Mycobacterium tuberculosis effector PPE36 attenuates host cytokine storm damage via inhibiting macrophage M1 polarization.

Journal of cellular physiology - 1 Nov 2021

Gong Zhen, Han Shuang, Liang Tian, Zhang Hongyang, Sun Qingyu, Pan Huimin, Wang Haolin, Yang Jiao, Cheng Liting, Lv Xi, Yue Qijia, Fan Lin, Xie Jianping

Abstract excerpt

Tuberculosis caused by Mycobacterium tuberculosis remains a serious global public health threat. Macrophage polarization is crucial for the innate immunity against M. tuberculosis. However, how M. tuberculosis interferes with macrophage polarization is elusive. We demonstrated here that M. tuberculosis PPE36 (Rv2108) blocked macrophage M1 polarization, preventing the cytokine storm, and alleviating inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33959974
DOI: 10.1002/jcp.30411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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