Article
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Communications biology - 23 Sept 2020
Nakamura Ryoichi, Misawa Kazuharu, Tohnai Genki, Nakatochi Masahiro, Furuhashi Sho, Atsuta Naoki, Hayashi Naoki, Yokoi Daichi, Watanabe Hazuki, Watanabe Hirohisa, Katsuno Masahisa, Izumi Yuishin, Kanai Kazuaki, Hattori Nobutaka, Morita Mitsuya, Taniguchi Akira, Kano Osamu, Oda Masaya, Shibuya Kazumoto, Kuwabara Satoshi, Suzuki Naoki, Aoki Masashi, Ohta Yasuyuki, Yamashita Toru, Abe Koji, Hashimoto Rina, Aiba Ikuko, Okamoto Koichi, Mizoguchi Kouichi, Hasegawa Kazuko, Okada Yohei, Ishihara Tomohiko, Onodera Osamu, Nakashima Kenji, Kaji Ryuji, Kamatani Yoichiro, Ikegawa Shiro, Momozawa Yukihide, Kubo Michiaki, Ishida Noriko, Minegishi Naoko, Nagasaki Masao, Sobue Gen
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought to have multifactorial pathogenesis. To understand the genetics of sporadic ALS, we conducted a genome-wide association study using 1,173 sporadic ALS cases and 8,925 controls in a Japanese population. A combined meta-analysis of our...
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