Article
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports - 22 Sept 2020
Xu Guoyue, van Bruggen Rebekah, Gualtieri Christian O, Moradin Neda, Fois Adrien, Vallerand Diane, De Sa Tavares Russo Mariana, Bassenden Angelia, Lu Wenyun, Tam Mifong, Lesage Sylvie, Girouard Hélène, Avizonis Daina Zofija, Deblois Geneviève, Prchal Josef T, Stevenson Mary, Berghuis Albert, Muir Tom, Rabinowitz Joshua, Vidal Silvia M, Fodil Nassima, Gros Philippe
Abstract excerpt
The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate mutase (BPGM) acts as a key allosteric regulator of hemoglobin/oxyhemoglobin. We demonstrate here that a loss-of-function mutation in the murine Bpgm (BpgmL166P) gene confers...
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