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Article

Tertiary structural elements determine the extent and specificity of messenger RNA editing.

Nature communications - 1 Jan 2013

Rieder Leila E, Staber Cynthia J, Hoopengardner Barry, Reenan Robert A

Abstract excerpt

The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here we surgically alter conserved cis elements associated with a cluster of ADAR modification sites within the endogenous Drosophila paralytic transcript. In addition to the local requirement for a central imperfect RNA duplex containing the modified...

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Share to Adenosine Deaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23903876
DOI: 10.1038/ncomms3232

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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