Article
Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis.
Blood - 24 Dec 2020
Miller Peter G, Sperling Adam S, Gibson Christopher J, Viswanathan Kaushik, Castellano Cecilia, McConkey Marie, Ceremsak John, Taylor Martin S, Birndt Sebastian, Perner Florian, Arnason Jon, Agrawal Mridul, Schram Alison M, Nikiforow Sarah, Pihan German, Hasserjian Robert P, Aster Jon C, La Rosée Paul, Morgan Elizabeth A, Berliner Nancy, Ebert Benjamin L
Abstract excerpt
Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. Unlike pediatric HLH, adult HLH is rarely driven by germline genetic variants. Although numerous precipitating etiologies have been identified, the reason that HLH occurs in only a subset of individuals and how other factors contribute to the disease remains unknown. We hypothesized that clonal...
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