Genetic Basis Underlying the Hyperhemolytic Phenotype of Streptococcus agalactiae Strain CNCTC10/84.

doi:10.1128/JB.00504-20

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Article

Genetic Basis Underlying the Hyperhemolytic Phenotype of Streptococcus agalactiae Strain CNCTC10/84.

Journal of bacteriology - 4 Nov 2020

Zhu Luchang, Beres Stephen B, Yerramilli Prasanti, Pruitt Layne, Cantu Concepcion C, Olsen Randall J, Musser James M

Abstract excerpt

Streptococcus agalactiae (group B streptococcus [GBS]) is a major cause of infections in newborns, pregnant women, and immunocompromised patients. GBS strain CNCTC10/84 is a clinical isolate that has high virulence in animal models of infection and has been used extensively to study GBS pathogenesis. Two unusual features of this strain are hyperhemolytic activity and hypo-CAMP factor activity. These two...

Topics

Bacterial Proteins
Base Sequence
Gene Expression Regulation, Bacterial
Hemolysis
Histidine Kinase
Humans
Phenotype
Point Mutation
Promoter Regions, Genetic
Streptococcal Infections
Streptococcus agalactiae
Virulence Factors

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Identifiers

PMID: 32958630
DOI: 10.1128/JB.00504-20
PMCID: PMC7648153

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