Article
Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism.
American journal of human genetics - 8 Apr 2011
Erez Ayelet, Shchelochkov Oleg A, Plon Sharon E, Scaglia Fernando, Lee Brendan
Abstract excerpt
Mutations in genes that play fundamental roles in metabolic pathways have been found to also play a role in tumor development and susceptibility to cancer. At the same time, significant progress has been made in the treatment of patients with inborn errors of metabolism (IEM),(1) resulting in increased longevity and the unmasking of cancer predisposition, frequently hepatocellular carcinoma, in these conditions....
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