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Role of Hydrazine-Related Chemicals in Cancer and Neurodegenerative Disease

11 Aug 2021

Abstract excerpt

Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in certain mushrooms and plants used for food and in products employed in various industries, including aerospace. Their propensity to induce DNA damage (mostly O 6 -, N 7 - and 8-oxo-guanine lesions) resulting in multiple downstream effects is linked with both cancer and neurological disease. For cycling cells, unrepaired DNA...

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PMID: 34379394
DOI: 10.1021/acs.chemrestox.1c00150

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