Article
Mutation analysis of LRP10 in a large Chinese familial Parkinson disease cohort.
Neurobiology of aging - 1 Mar 2021
Li ChunYu, Chen YongPing, Ou RuWei, Gu XiaoJing, Wei QianQian, Cao Bei, Zhang LingYu, Hou YanBing, Liu KunCheng, Chen XuePing, Song Wei, Zhao Bi, Wu Ying, Shang HuiFang
Abstract excerpt
Recently, LRP10 has been identified as a causative gene for Parkinson's disease (PD). However, subsequent studies showed inconsistent conclusions. To explore its relevance to PD, we systematically analyzed LRP10 rare mutations in a large Han Chinese familial PD cohort of 385 unrelated probands using segregation analysis, transcriptional effect analysis, and burden test. As a result, 3 missense variants and 1...
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