Article
Rare, pathogenic variants in LRP10 are associated with amyotrophic lateral sclerosis in patients from mainland China.
Neurobiology of aging - 1 Jan 2021
Ni Jie, Liu Zhen, Li Wanzhen, Yuan Yanchun, Huang Ling, Hu Yiting, Liu Pan, Hou Xiaorong, Jiao Bin, Li Jinchen, Shen Lu, Jiang Hong, Tang Beisha, Wang Junling
Abstract excerpt
Low-density lipoprotein receptor-related protein 10 (LRP10) is associated with a series of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease which share genetic risk factors and pathophysiological processes with amyotrophic lateral sclerosis (ALS). To investigate whether LRP10 variants could cause a predisposition to ALS, we screened rare, pathogenic LRP10 variants among a cohort of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.