Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting MicroRNA-485-3p Blocks Alzheimer’s Disease Progression

4 Dec 2021

Abstract excerpt

Alzheimer's disease (AD) is a form of dementia characterized by progressive memory decline and cognitive dysfunction. With only one FDA-approved therapy, effective treatment strategies for AD are urgently needed. In this study, we found that microRNA-485-3p (miR-485-3p) was overexpressed in the brain tissues, cerebrospinal fluid, and plasma of patients with AD, and its antisense oligonucleotide (ASO) reduced Aβ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to MicroRNA in disease regulation
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34884940
DOI: 10.3390/ijms222313136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting MicroRNA-485-3p Blocks Alzheimer’s Disease ProgressionPMID 34884940Read ↗

miRNAs as Therapeutic Tools in Alzheimer’s DiseaseSemantic proximity Read ↗

MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapySemantic proximity Read ↗

Therapeutic potential and microRNA regulating properties of phytochemicals in Alzheimer’s diseaseSemantic proximity Read ↗

Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious UpdateSemantic proximity Read ↗

Potential Implications of miRNAs in the Pathogenesis, Diagnosis, and Therapeutics of Alzheimer’s DiseaseSemantic proximity Read ↗

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer’s disease mouse modelSemantic proximity Read ↗

Insights into the Role of microRNAs as Clinical Tools for Diagnosis, Prognosis, and as Therapeutic Targets in Alzheimer’s DiseaseSemantic proximity Read ↗

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer’s diseaseSemantic proximity Read ↗

The emerging role of microRNA-4487/6845-3p in Alzheimer’s disease pathologies is induced by Aβ25–35 triggered in SH-SY5Y cellSemantic proximity Read ↗

MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read ↗

MicroRNA-511-3p regulates Aβ1–40 induced decreased cell viability and serves as a candidate biomarker in Alzheimer's diseaseSemantic proximity Read ↗

Epigenetic Regulation of Neuroinflammation Leading to Dementia of Alzheimer’s Disease and Other Forms of DementiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.