Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populations.

Human genetics - 1 Nov 2004

Caldwell Elizabeth F, Mayor Lianne R, Thomas Mark G, Danpure Christopher J

Abstract excerpt

The intermediary metabolic enzyme alanine:glyoxylate aminotransferase (AGT) contains a Pro11Leu polymorphism that decreases its catalytic activity by a factor of three and causes a small proportion to be mistargeted from its normal intracellular location in the peroxisomes to the mitochondria. These changes are predicted to have significant effects on the synthesis and excretion of the metabolic end-product...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catalysis

Share to Mouth Mucosa

Share to Statistics as Topic

Share to Transaminases

Share to White People

Source

Identifiers

PMID: 15480793
DOI: 10.1007/s00439-004-1191-x

Genes

AGT
FST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populations.PMID 15480793Read ↗

Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene.Semantic proximity Read ↗

Molecular Aetiology of Primary Hyperoxaluria Type 1Semantic proximity Read ↗

Recent advances in understanding the adaptive evolution of metabolic genes and traits.Semantic proximity Read ↗

Aberrant One-Carbon Metabolism and Ancestral Genetics Underlie Edematous Severe Acute MalnutritionSemantic proximity Read ↗

Liver peroxisomal alanine:glyoxylate aminotransferase and the effects of mutations associated with Primary Hyperoxaluria Type I: An overview.Semantic proximity Read ↗

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamicsSemantic proximity Read ↗

Food made us human: Recent genetic variability and its relevance to the current distribution of macronutrientsSemantic proximity Read ↗

Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism.Semantic proximity Read ↗

Genetic explorations of recent human metabolic adaptations: hypotheses and evidence.Semantic proximity Read ↗

The Associations of Genetically Predicted Plasma Alanine with Coronary Artery Disease and its Risk Factors: A Mendelian Randomization Study.Semantic proximity Read ↗

Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations.Semantic proximity Read ↗

The ILE56 mutation on different genetic backgrounds of alanine:glyoxylate aminotransferase: Clinical features and biochemical characterization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.