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Article

Emphysema and airway disease synergistically impair exercise tolerance in smokers: A CT-based study.

Respiratory physiology & neurobiology - 1 Jan 2026

Maetani Tomoki, Sugitani Taketo, Tanabe Naoya, Shiraishi Yusuke, Hayashi Yusuke, Oguma Tsuyoshi, Sakamoto Ryo, Ikeda Kaori, Oshima Yohei, Yoshioka Yuji, Hamada Ryota, Sato Atsuyasu, Sato Susumu, Ikeguchi Ryosuke, Hirai Toyohiro

Abstract excerpt

INTRODUCTION: Emphysema and airway disease are major pathological features in smokers, including those with chronic obstructive pulmonary disease (COPD); however, how these two distinct pathologies interact to impair exercise capacity remains poorly understood. This study aimed to comprehensively compare physical performance, body composition, and physical activity across four computed tomography (CT)-based...

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Identifiers

PMID: 42336306
DOI: 10.1016/j.resp.2026.104612

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