Article
Generalizability of "GWAS Hits" in Clinical Populations: Lessons from Childhood Cancer Survivors.
American journal of human genetics - 1 Oct 2020
Im Cindy, Qin Na, Wang Zhaoming, Qiu Weiyu, Howell Carrie R, Sapkota Yadav, Moon Wonjong, Chemaitilly Wassim, Gibson Todd M, Mulrooney Daniel A, Ness Kirsten K, Wilson Carmen L, Morton Lindsay M, Armstrong Gregory T, Bhatia Smita, Zhang Jinghui, Hudson Melissa M, Robison Leslie L, Yasui Yutaka
Abstract excerpt
With mounting interest in translating genome-wide association study (GWAS) hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here, we consider long-term survivors of childhood cancers from the St. Jude Lifetime Cohort Study, and we show the limited generalizability of 1,376 robust SNP associations reported in the general...
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