Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

doi:10.1200/JCO.23.02281

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Article

Trans-Ancestral Genetic Risk Factors for Treatment-Related Type 2 Diabetes Mellitus in Survivors of Childhood Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2024

Im Cindy, Neupane Achal, Baedke Jessica L, Lenny Brian, Delaney Angela, Dixon Stephanie B, Chow Eric J, Mostoufi-Moab Sogol, Yang Tianzhong, Richard Melissa A, Gramatges M Monica, Lupo Philip J, Sharafeldin Noha, Bhatia Smita, Armstrong Gregory T, Hudson Melissa M, Ness Kirsten K, Robison Leslie L, Yasui Yutaka, Wilson Carmen L, Sapkota Yadav

Abstract excerpt

PURPOSE: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D. PATIENTS AND METHODS: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted...

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Identifiers

PMID: 38652878
DOI: 10.1200/JCO.23.02281
PMCID: PMC11209771

Genes

ZNF492
MYT1L

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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