Article

Generalizability of “GWAS hits” in clinical populations: Lessons from childhood cancer survivors

2020-02-02

Abstract excerpt

<h4>ABSTRACT</h4> With mounting interest in translating GWAS hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here we consider long-term survivors of childhood cancers from the St. Jude Lifetime Cohort Study and show the limited generalizability of 1,376 robust SNP associations reported in the general population across 12 c...

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Literature Corpus work: 47ae953b-e738-596b-b676-0d1b9c7b2a84
DOI: 10.1101/2020.02.02.930818

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