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Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge

3 Dec 2020

Abstract excerpt

The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approvals of sofosbuvir and remdesivir against Hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus 2...

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PMID: 33287144
DOI: 10.3390/molecules25235695

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