Article
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.
PLoS genetics - 1 Nov 2017
Fernández Maria Victoria, Kim Jong Hun, Budde John P, Black Kathleen, Medvedeva Alexandra, Saef Ben, Deming Yuetiva, Del-Aguila Jorge, Ibañez Laura, Dube Umber, Harari Oscar, Norton Joanne, Chasse Rachel, Morris John C, Goate Alison, Cruchaga Carlos
Abstract excerpt
Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap. Previous studies indicate that causative mutations in AD and FTD/ALS genes can be found in clinical familial AD. We examined the presence of causative and low frequency coding variants in the AD, FTD, ALS and PD...
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