Article
Parallel Analysis of Pre- and Postoperative Circulating Tumor DNA and Matched Tumor Tissues in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Cohort Study.
Clinical chemistry - 6 Dec 2022
Lee Jee-Soo, Han Youngmin, Yun Won-Gun, Kwon Wooil, Kim Hongbeom, Jeong Hyeonju, Seo Myoung-Seock, Park Yongsook, Cho Sung Im, Kim Haeryoung, Kim Ji Yeon, Seong Moon-Woo, Jang Jin-Young, Park Sung Sup
Abstract excerpt
BACKGROUND: Circulating tumor DNA (ctDNA) is a promising biomarker for early tumor detection and minimal residual disease (MRD) assessment in early-stage cancer, but quantifying minute amounts of ctDNA is challenging and well-designed studies on ctDNA in early-stage cancer are still lacking. Here, we adapted a sensitive next-generation sequencing (NGS) technology and performed parallel analysis of pre- and...
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