Article
Hippocampal blood-brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jun 2021
Moon Won-Jin, Lim Changmok, Ha Il Heon, Kim Yeahoon, Moon Yeonsil, Kim Hee-Jin, Han Seol-Heui
Abstract excerpt
Blood-brain barrier (BBB) disruption, modulated by APOE4 mutation, is implicated in the pathogenesis of cognitive decline. We determined whether BBB permeability differed according to cognitive functioning and APOE4 status in elderly subjects without dementia. In this prospective study, 33 subjects with mild cognitive impairment (MCI) and 33 age-matched controls (normal cognition [NC]) underwent 3 T brain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.