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Article

The clinical consequences of strain diversity in Mycobacterium tuberculosis.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Oct 2008

Nicol Mark P, Wilkinson Robert J

Abstract excerpt

The influence of strain variation on the outcome of infection with Mycobacterium tuberculosis is an emerging area of research. Significant genetic diversity is generated within the species through deletion, duplication and recombination events; however, unlike many bacterial pathogens gene exchange is rare in M. tuberculosis, resulting in the evolution of distinct clonal lineages. One such lineage, W-Beijing, is...

Topics

Bacterial Proteins
Genotype
Humans
Mutagenesis, Insertional
Mycobacterium tuberculosis
Polymorphism, Genetic
Tuberculosis
Virulence

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18513773
DOI: 10.1016/j.trstmh.2008.03.025

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