Lessons from molecular epidemiology and comparative genomics.

doi:10.1055/s-0028-1085699

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Article

Lessons from molecular epidemiology and comparative genomics.

Seminars in respiratory and critical care medicine - 1 Oct 2008

Mathema Barun, Kurepina Natalia, Fallows Dorothy, Kreiswirth Barry N

Abstract excerpt

Molecular biology has revolutionized the field of tuberculosis (TB) research. Comparative genomics and molecular epidemiology are providing revelations about the evolutionary origins of MYCOBACTERIUM TUBERCULOSIS and phylogenetic relationships between different strains and strain families. Accumulating evidence indicates that distinct strains of M. TUBERCULOSIS (genotype) may be associated with differential...

Topics

Antitubercular Agents
Drug Resistance, Bacterial
Genomics
Genotype
Humans
Molecular Epidemiology
Mycobacterium tuberculosis
Phenotype
Phylogeny
Tuberculosis
Virulence

Source

Open in PubMed

Identifiers

PMID: 18810681
DOI: 10.1055/s-0028-1085699

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