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Article

Notch signaling mutations increase intra-tumor chemokine expression and predict response to immunotherapy in colorectal cancer.

BMC cancer - 29 Aug 2022

Wang Fei, Huang Chuan, Long Jie, Zhao Zhi-Bin, Ma Hai-Qing, Yao Xue-Qing, Li Liang, Lian Zhe-Xiong

Abstract excerpt

BACKGROUND: The Notch signaling mutation is associated with enhanced anti-tumor immune response in colorectal cancer (CRC). In this study, we aim to investigate the underlying mechanism and the predictive potential of Notch signaling mutation for responding to immunotherapy in CRC. METHODS: We analyzed the immune response associated genes in CRC with Notch signaling mutation concomitant with or without...

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Source

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Identifiers

PMID: 36038820
DOI: 10.1186/s12885-022-10032-5
PMCID: PMC9426242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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