Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas.

doi:10.1007/s10238-025-01825-6

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Article

Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas.

Clinical and experimental medicine - 31 Oct 2025

Luo Yang, Wang Roushu, Xu Yu, He Mengjiang, Zhou Qiaoxia, Wang Guoqiang, Ye Guangyao, Xu Chunwei, Wang Wenxian, Cai Shangli, Peng Feng, Zhu Xu

Abstract excerpt

The Notch pathway regulates the homeostasis and tumorigenesis of gastrointestinal epithelium. Given its roles in cancer stem cell capacity and cancer immunity, we hypothesized that Notch activation can predict poor prognosis and resistance to immune checkpoint inhibitors (ICIs) in gastrointestinal adenocarcinoma (GIAC). The mRNA expression and genomic alterations of Notch pathway were characterized in esophagus...

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Topics

Humans
Immune Checkpoint Inhibitors
Adenocarcinoma
Drug Resistance, Neoplasm
Receptors, Notch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Signal Transduction

Prognosis

Gastrointestinal Neoplasms

Phenotype

Gene Expression Regulation, Neoplastic

Female

Male

Gene Expression Profiling

Source

Open in PubMed Open full text

Identifiers

PMID: 41171465
DOI: 10.1007/s10238-025-01825-6
PMCID: PMC12578743

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