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The impact of MCP1-2518A/G and CCR2-V64I genetic polymorphisms in Egyptian sickle cell disease patients.

Experimental and molecular pathology - 1 Oct 2022

Ibrahim Nihal Salah, Makhlouf Manal Mohamed, Shahin Gehan Hamed, Elghamrawy Mona Kamal, Hussein Nehad Mohammed

Abstract excerpt

BACKGROUND: Sickle cell disease (SCD) is an inherited genetic disorders of hemoglobin that causes multisystem morbidity. The pathophysiology of SCD is complex and includes HbS polymerization/sickling, hemolysis, endothelial dysfunction and inflammation. Chemokines are proteins playing an important role in the inflammation process and could be involved the context of pro-inflammatory SCD. Some chemokine...

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PMID: 36155203
DOI: 10.1016/j.yexmp.2022.104834

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