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Article

Primary cilium-dependent cAMP/PKA signaling at the centrosome regulates neuronal migration

2 Sept 2020

Abstract excerpt

The primary cilium (PC) is a small centrosome-assembled organelle, protruding from the surface of most eukaryotic cells. It plays a key role in cell migration, but the underlying mechanisms are unknown. Here, we show that the PC regulates neuronal migration via cyclic adenosine 3'-5' monosphosphate (cAMP) production activating centrosomal protein kinase A (PKA). Biosensor live imaging revealed a periodic cAMP...

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PMID: 32917588
DOI: 10.1126/sciadv.aba3992

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