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Article

Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium.

Developmental biology - 1 Aug 2025

Sheridan Jennifer, Grata Aline, Dorr Julia, Suva Eve E, Bresteau Enzo, Mitchell Linus R, Hassan Osama, Mitchell Brian

Abstract excerpt

The skin of Xenopus embryos contains numerous multiciliated cells (MCCs), which collectively generate a directed fluid flow across the epithelial surface essential for distributing the overlaying mucous. MCCs develop into highly specialized cells to generate this flow, containing approximately 150 evenly spaced centrioles that give rise to motile cilia. MCC-driven fluid flow can be impaired when ciliary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40381709
DOI: 10.1016/j.ydbio.2025.05.011
PMCID: PMC12184093

Genes

AK7
MCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium.PMID 40381709Read ↗

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