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Article

FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair.

Stem cell reports - 13 Oct 2020

Julien Anais, Perrin Simon, Duchamp de Lageneste Oriane, Carvalho Caroline, Bensidhoum Morad, Legeai-Mallet Laurence, Colnot Céline

Abstract excerpt

Most organs and tissues in the body, including bone, can repair after an injury due to the activation of endogenous adult stem/progenitor cells to replace the damaged tissue. Inherent dysfunctions of the endogenous stem/progenitor cells in skeletal repair disorders are still poorly understood. Here, we report that Fgfr3Y637C/+ over-activating mutation in Prx1-derived skeletal stem/progenitor cells leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32916123
DOI: 10.1016/j.stemcr.2020.08.005
PMCID: PMC7561512

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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