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Article

Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation.

Biochemical and biophysical research communications - 21 Nov 2008

Su Nan, Yang Jing, Xie Yixia, Du Xiaolan, Lu Xiumin, Yin Zhiyong, Yin Liangjun, Qi Huabing, Zhao Ling, Feng Jianquan, Chen Lin

Abstract excerpt

Fracture healing is a complicated regeneration process which to some extent recapitulates bone development. Fibroblast growth factor receptor 3 (FGFR3) has a negative regulatory effect on endochondral ossification, and FGFR3 is also expressed in prehypertrophic and hypertrophic chondrocytes during fracture healing. However, the actual role of FGFR3 during bone regeneration is not fully understood. Therefore we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Identifiers

PMID: 18789890
DOI: 10.1016/j.bbrc.2008.08.165

Genes

FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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